Fioricet is a combination prescription medication used to treat tension headaches caused due to muscle contractions. The medicine contains several active ingredients:
The medication is useful in treating tension headaches, post-dural headaches, and headaches caused by muscle contractions in the skull. A doctor may also prescribe Fioricet capsules for some other conditions. The Food and Drug Administration (FDA) approved a combination of Fioricet with codeine to treat and manage migraines.
Each of the ingredients of Fioricet stays in the system for different lengths of time. As a result, the Fioricet pill can stay in the system for up to eight days.
The effects of Fioricet last for about 3-6 hours. It is usually prescribed by doctors as one to two capsules every 4-6 hours as required.
The half-life of any substance is the time it takes for half of the substance’s dose to eliminate from your bloodstream. Each ingredient of Fioricet capsules has a distinct half-life:
- Acetaminophen half-life: 2 hours
- Butalbital half-life: 36 hours
- Caffeine half-life: 6 hours
Your body takes about five half-lives to eliminate Fioricet fully. The other two ingredients, Acetaminophen leaves the body in 10 hours and caffeine in about 30 hours.
Butalbital is a barbiturate having the longest half-life. The elimination time of Fioricet depends upon the elimination of Butalbital due to its most extended half-life. The substance takes about 180 hours (or almost 8 days) to leave your system.
How long will Fioricet show in drug tests?
Most of the standard drug screening tests look for barbiturates, including Butalbital present in Fioricet. Many drug test screenings may show traces of Fioricet for different lengths of time.
Some factors affect the detection window of Fioricet; however, most urine tests detect Butalbital use for 3-7 days following the last dose of Fioricet.
Butalbital is a relatively long half-life and is present in the blood for about 8 days. However, blood tests are not commonly used to detect Fioricet use as they are invasive and expensive.
The primary ingredient of Fioricet capsules, Butalbital, is detectable in saliva for 2-3 days.
Almost all substances have a similar window of detection for hair tests. The use of Butalbital deposits the medication into hair follicles and gets locked in the hair. Fioricet use can be detected for 90 days in hair after taking 1.5 centimeters of hair.
Factors affecting how long Fioricet stays in your system
Several factors influence how long Fioricet stays in your system, including:
- Frequency of use
- Amount used
- Overall health
- Age and other personal factors
The detection window of Fioricet capsules is mostly affected by the amount of dose you used and how frequently you take the medication. The body takes a long duration time window to metabolize Butalbital, so it gets accumulates only after a few doses and is usually detectable in your body for about a week.
False Positives of Fioricet Pills
Concomitant use of non-steroidal anti-inflammatory drugs (NSAIDs) such as naproxen and ibuprofen can trigger false positives of Butalbital; however, it happens less than one percent of the time.
A positive test will be sent to some other lab for a particular confirmation test called GC-MS (gas chromatography-mass spectrometry). GC-MS tests are precise and sensitive, so they do not produce false reports (false-positives).
How is Fioricet broken down in your body?
Kidneys mostly filter out Butalbital from the blood and remove it through urine. Caffeine and acetaminophen get metabolized and removed by your liver.
How to get Fioricet out of the system?
The only way to remove Fioricet pills from your system is to wait for the medication’s appropriate length of time to get out of the body. Organs that metabolize the substances present in Fioricet, like kidney that metabolizes Butalbital, require an appropriate amount of time to eliminate.
Highlights: How long does Fioricet stay in your system?
- Fioricet capsules contain three different ingredients: Acetaminophen, Butalbital, and caffeine.
- The medication’s most widely used strength is Fioricet 40mg, which contains 300mg or 325mg Acetaminophen, 40mg Butalbital, and 50mg Caffeine.
- All three ingredients of Fioricet pills are detectable in your system for different time durations.
- Butalbital half-life is 36 hours, acetaminophen half-life is 2 hours, and caffeine half-life is 6 hours.
- Butalbital, the main ingredient of Fioricet, can be detectable in different drug screening tests.
- Butalbital may take several days to leave your system and body, sometimes over a week.
- Most drug screening tests detect Butalbital for one week and longer.